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        <div id="content-top1">Page 17 - Putech&Composites KasÄ±m-AralÄ±k'20 SayÄ± 54 </div>
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    <pre style="white-space:pre-line"><code>Makale

  Åekil 10. Stevia glikozit bazlÄ± PU/PCL liflerinin SEM        moplastik PU (TPU)/PCL/PEG, tamamen rastgele fiber
                 gÃ¶rÃ¼ntÃ¼leri [AteÅŸ vd., 2020].                 tabakasÄ± (RLTS) ile FLTSâ€™leri Ã¼retmek iÃ§in elektroeÄŸi-
                                                               rilmiÅŸtir. Elde edilen nanofiberlerin SEM gÃ¶rÃ¼ntÃ¼le-
Biyo-Ã¼retim tekniklerinin geliÅŸtirilmesi, doku mÃ¼hendis-       ri Åekil 12â€™de verilmiÅŸtir. TPU/PCL/PEG FLTSâ€™nin yÃ¼zey
liÄŸi alanÄ±nda ilerlemelere, Ã¶zellikle de doÄŸal dokularÄ±n       Ä±slanabilirliÄŸi, su temas aÃ§Ä±sÄ± analizi ile test edilmiÅŸ ve
fizyolojik karmaÅŸÄ±klÄ±ÄŸÄ±nÄ± taklit eden doku ikamelerinin        RLTSâ€™ler ile kÄ±yaslandÄ±ÄŸÄ±nda FLTSâ€™ler, daha yÃ¼ksek Ã§ev-
Ã¼retilmesine yol aÃ§mÄ±ÅŸtÄ±r. Transplantasyon, dÃ¼nya Ã§a-          resel ve uzunlamasÄ±na gerilme Ã¶zellikleri ile mÃ¼kemmel
pÄ±nda milyonlarca kardiyovaskÃ¼ler hastalÄ±k hastasÄ± iÃ§in        mekanik Ã¶zellikler gÃ¶sterdiÄŸi kaydedilmiÅŸtir. AyrÄ±ca,
etkili bir klinik stratejidir. VaskÃ¼ler greftler, kardiyovas-  FLTSâ€™ler Ã¼zerinde insan umbilikal ven endotel hÃ¼cre-
kÃ¼ler hastalÄ±klarÄ±n tedavisinde olduÄŸu kadar diyaliz, pe-      lerinin (HUVECâ€™ler) yÃ¼ksek canlÄ±lÄ±ÄŸÄ±, RLTSâ€™lere kÄ±yasla
diatrik kalp cerrahisi ve mezenterik iskemi tedavisi gibi      tÃ¼bÃ¼ler yapÄ± iskeletlerinin biyouyumluluÄŸunu gÃ¶ster-
diÄŸer klinik uygulamalarda da kullanÄ±lmaktadÄ±r. Damar          miÅŸtir. FLTSâ€™lerin dÃ¼zenlenmiÅŸ ve rastgele kompozit ya-
iskeletleri ile kan damarÄ± nakillerinin baÅŸarÄ±sÄ±, bÃ¼yÃ¼k        pÄ±sÄ± HUCEVâ€™lerin bÃ¼yÃ¼mesini teÅŸvik etmek iÃ§in kullanÄ±ÅŸlÄ±
Ã¶lÃ§Ã¼de yapÄ±larÄ±na ve mekanik Ã¶zelliklerine baÄŸlÄ±dÄ±r.           olduÄŸu doÄŸrulanmÄ±ÅŸ ve bu iskeletler Ã¼zerindeki hÃ¼cre
Caiping Su ve arkadaÅŸlarÄ± yaptÄ±klarÄ± Ã§alÄ±ÅŸmada tasarÄ±m         yapÄ±ÅŸmasÄ± ve Ã§oÄŸalmasÄ±nÄ±n, RLTSâ€™lerden Ã¼stÃ¼n olduÄŸu
gereksinimlerini yÃ¼ksek hassasiyetle karÅŸÄ±lamak iÃ§in ye-       kanÄ±tlanmÄ±ÅŸtÄ±r. Bu sonuÃ§lar Ä±ÅŸÄ±ÄŸÄ±nda Ã¼retilen FLTSâ€™lerin
nilikÃ§i bir 3D baskÄ± yÃ¶ntemi ile Ã§ok katmanlÄ± boru ÅŸek-        vaskÃ¼ler doku rejenerasyonunda ve klinik arteriyel rep-
linde PU temelli bir iskelet Ã¼retmek iÃ§in yeni bir yÃ¶ntem      lasmanlarda uygulama potansiyelinin yÃ¼ksek olduÄŸu
geliÅŸtirmiÅŸlerdir. Kompozit malzemeler ve dÃ¼zenlenmiÅŸ          gÃ¶rÃ¼lmÃ¼ÅŸtÃ¼r [Su vd., 2020].
katmanlarÄ±n kombinasyonunun, boru ÅŸeklindeki iske-
letlerin mevcut sÄ±nÄ±rlamalarÄ±nÄ± Ã§Ã¶zebileceÄŸini ve dÃ¶rt             Åekil 11. (a) doÄŸal kan damarÄ± ve (b) kÃ¼Ã§Ã¼k Ã§aplÄ±
kompozit tabakalÄ± boru ÅŸeklideki bir yapÄ±nÄ±n Ã¼retimi-           FLTSâ€™lerin ÅŸematik diyagramÄ±. FLTSâ€™lerin Ã¼retimi: (c) iÃ§
nin mÃ¼mkÃ¼n olabileceÄŸi Ã¶ngÃ¶rÃ¼lmÃ¼ÅŸtÃ¼r. DÃ¼zenlenmiÅŸ               katman, (d) orta-iÃ§ katman, (e) orta-dÄ±ÅŸ katman ve (f)
fiberlerle dÃ¶rt katmanlÄ± boru ÅŸeklinde Ã¼retilen iskelet-
lerde (FLTS); iki orta katman, doÄŸal kan damarlarÄ±nÄ±n                             dÄ±ÅŸ katman [Su vd., 2020].
tunika ortamÄ±nÄ± taklit etmekte ve gerekli mekanik gÃ¼cÃ¼
saÄŸladÄ±ÄŸÄ± doÄŸrulanmÄ±ÅŸtÄ±r. DoÄŸal kan damarÄ± ve kÃ¼Ã§Ã¼k
Ã§aplÄ± FLTSâ€™lerin ÅŸematik gÃ¶sterimleri Åekil 11â€™de veril-
miÅŸtir. FarklÄ± ÅŸekilde yÃ¶nlendirilmiÅŸ fiberlere sahip dÃ¶rt
katman, bir mandrel toplayÄ±cÄ± kullanÄ±larak elektroeÄŸir-
me yÃ¶ntemi ile Ã¼retilmiÅŸtir. Sadece endotel hÃ¼crelerini
(EC) eÄŸitici topografik ipuÃ§larÄ± kullanarak dÃ¼zenlemeyi
deÄŸil, aynÄ± zamanda bunlarÄ±n proliferasyonunu ve ya-
pÄ±ÅŸmasÄ±nÄ± artÄ±rmayÄ± ve FLTSâ€™lerin mekanik Ã¶zelliklerini
iyileÅŸtirmeyi amaÃ§lanmÄ±ÅŸtÄ±r. GeliÅŸtirilen FLTSâ€™ler ter-

                                                               Putech & Composites                                          15</code></pre>
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