<html xmlns="http://www.w3.org/1999/xhtml"><head>
        <meta http-equiv="Content-Type" content="text/html; charset=utf-8">
        <meta name="viewport" content="width=device-width, height=device-height, initial-scale=0.5, minimum-scale=0.5, user-scalable=yes, maximum-scale=2.0, target-densitydpi=device-dpi" />
				<meta name="robots" content="all"/>
        <meta name="description" content="description">
        <meta name="keywords" content="">
        <title>Page 74 - Turkchem Temmuz AÄŸustos 2016 - SayÄ± 52</title>
<style type="text/css">
<!--
body {
	margin-left: 0px;
	margin-top: 0px;
	margin-right: 0px;
	margin-bottom: 0px;
}
  
#container {margin:50px auto;padding:0px;width:910px;}
#left-button{ width:90px; height:100%;float:left }
#middle{ width:730px; margin:0px; float: left;}
#right-button{ width:90px; float:left;}
html, body, div, ul, li, dl, dt, dd, h1, h2, h3, h4, h5, h6, form, input, dd,select, button, textarea, iframe, table, th, td { margin: 0; padding: 0; }
img { border: 0 none; displayblock}
span,ul,li,image{ padding:0px; margin:0px; list-style:none;}
#top-title{ width:714px; margin-bottom:10px; float:left; padding:0px 8px}
#top-title2{ width:320px;  float:right;}
#content{ width: 730px; float:left;float:left;word-wrap: break-word;}
#content-top{ width:730px; background-image:url(images/top_bg.jpg); height:56px; background-repeat:no-repeat; float:left;}
#content-top1{ width:70%; padding:16px 0px 0px 30px; font-family:Arial, Helvetica, sans-serif; font-size:24px; color:#636363;float:left;}
#content-top2{ width:60px; float:right; padding:25px 30px 0px 0px;font-family:Arial, Helvetica, sans-serif; font-size:11px; color:#2f2f2f; font-weight:bold; text-align:right}
#content-middle{ width:730px; background-image:url(images/middle_bg.jpg); background-repeat:repeat-y;float:left;}
#content-middle1{ width:475px; padding:25px 0px 25px 35px; font-family:Arial, Helvetica, sans-serif; font-size:12px; color:#636363; line-height:150%;float:left;}
#content-middle2{  padding:7px; float:right; margin:25px 35px 0px 0px; border:solid 1px #c8c8c9; background-color:#FFF; text-align:center}
#content-bottom{ width:730px; background-image:url(images/bottom_bg.jpg); background-repeat:no-repeat; height:58px;float:left;}
#content-bottom2{ width:110px; height:42px; margin:0px auto; padding-top:4px;}
#input{ width:58px; height:20px; background-color:#FFF; border:solid 1px #dfdfe0; color:#636363; text-align:center; font-size:11px;}
.font1{ font-family:Arial, Helvetica, sans-serif; font-size:10px; color:#2f2f2f;}
.font1 a:link{
	text-decoration: none;
    color:#2f2f2f;

}
.font1 a:visited{
	text-decoration: none;
    color:#2f2f2f;
	
}
.font1 a:hover{
	color: #2f2f2f;
	text-decoration: underline;

}



.text-container {
padding: 20px;
color: #333;
margin-top: 24px;
line-height: 22px;
border-top-left-radius: 3px;
border-top-right-radius: 3px;
}

.use-as-video {
float: right;
padding-left: 20px;
}
.cc-float-fix:before, .cc-float-fix:after {
content: "";
line-height: 0;
height: 0;
width: 0;
display: block;
visibility: hidden;
}
.use-as-video-img {
cursor: pointer;
position: relative;
width: 320px;
height: 180px;
}
.use-as-video-title {
font-size: 15px;
font-weight: bold;
color: #000000;
padding-bottom: 5px;
}
-->
</style>
<script type="text/javascript">
<!--
function MM_preloadImages() { //v3.0
  var d=document; if(d.images){ if(!d.MM_p) d.MM_p=new Array();
    var i,j=d.MM_p.length,a=MM_preloadImages.arguments; for(i=0; i<a.length; i++)
    if (a[i].indexOf("#")!=0){ d.MM_p[j]=new Image; d.MM_p[j++].src=a[i];}}
}

function MM_swapImgRestore() { //v3.0
  var i,x,a=document.MM_sr; for(i=0;a&&i<a.length&&(x=a[i])&&x.oSrc;i++) x.src=x.oSrc;
}

function MM_findObj(n, d) { //v4.01
  var p,i,x;  if(!d) d=document; if((p=n.indexOf("?"))>0&&parent.frames.length) {
    d=parent.frames[n.substring(p+1)].document; n=n.substring(0,p);}
  if(!(x=d[n])&&d.all) x=d.all[n]; for (i=0;!x&&i<d.forms.length;i++) x=d.forms[i][n];
  for(i=0;!x&&d.layers&&i<d.layers.length;i++) x=MM_findObj(n,d.layers[i].document);
  if(!x && d.getElementById) x=d.getElementById(n); return x;
}

function MM_swapImage() { //v3.0
  var i,j=0,x,a=MM_swapImage.arguments; document.MM_sr=new Array; for(i=0;i<(a.length-2);i+=3)
   if ((x=MM_findObj(a[i]))!=null){document.MM_sr[j++]=x; if(!x.oSrc) x.oSrc=x.src; x.src=a[i+2];}
}
//-->
</script>
</head>

<body onload="MM_preloadImages('images/next2.png','images/previous2.png')">
<div id="container">
<div id="left-button">
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p><a href="page73.html"><img src="images/previous_big.png" width="90" height="80" /></a></p>
</div>
<div id="middle">
  <div id="top-title"><span class="font1">Basic HTML Version</span>
    <div id="top-title2">
      <table width="100%" border="0" align="right" cellpadding="0" cellspacing="0">
        <tr>
        	<td width="66%"> </td>
          <td width="35%" style="display:none" align="right"><img src="images/content.png" width="19" height="16" /></td>
          <td width="31%" style="display:none" class="font1"><a href="">Table of Contents</a></td>
          <td width="6%"><img src="images/view.png" width="19" height="16" /></td>
          <td width="28%" class="font1"><a href="../../index.html#p=74">View Full Version</a></td>
        </tr>
      </table>
    </div>
  </div>
  <div id="content">
     <div id="content-top">
        <div id="content-top1">Page 74 - Turkchem Temmuz AÄŸustos 2016 - SayÄ± 52</div>
        <div id="content-top2">P. 74</div>
     </div>
     <div id="content-middle">
     	
     	  <div class="text-container">
    <div class="use-as-video cc-float-fix">
      <a style="text-decoration: none;" href="../../index.html#p=74"><img src="../thumb/74.jpg" /></a>
    </div>

    <p class="use-as-video-title"></p>
    <pre style="white-space:pre-line"><code>ÃœrÃ¼n TanÄ±tÄ±mÄ± / Product Advertorial

                                                                          Åeyda YakÄ±nÃ§am

                                                                                                          SatÄ±ÅŸ Temsilcisi / Ä°laÃ§ KimyasallarÄ±
                                                                                                       Sales Representative / Health Care

                                                                                                                                  Croda Turkey

Super Refinedâ„¢ Arlasolveâ„¢ DMI Cilt Penetrasyonunu ArttÄ±rÄ±cÄ±

          Super Refinedâ„¢ Arlasolveâ„¢ DMI Enhancing Skin Penetration

Super Refined Arlasolve DMI (Dimetil Izosorbit) mÃ¼kem-         Super Refined Arlasolve DMI (Dimethyl Isosorbide) is a high
mel Ã§Ã¶zÃ¼cÃ¼ Ã¶zelliklere sahip yÃ¼ksek saflÄ±kta su gibi beyaz     purity, water white liquid with excellent solvent properties.
bir sÄ±vÄ±dÄ±r. Cildin ihtiyaÃ§ duyduÄŸu aktif bileÅŸenlerin taÅŸÄ±n-  It is a delivery enhancer which places active ingredients
masÄ±nÄ± arttÄ±rÄ±r.                                               where they are most needed in the skin.
Etken maddelerin yayÄ±lmasÄ±nÄ± iyileÅŸtirme ve taÅŸÄ±nmasÄ±nÄ± art-   As well as improving spreading and enhancing delivery of
tÄ±rma Ã¶zelliklerinin yanÄ±sÄ±ra, Super Refined Arlasolve DMI     actives, Super Refined Arlasolve DMI is produced to the
yÃ¼ksek saflÄ±k standartlarÄ±nda Ã¼retilmiÅŸtir. Super Refining,    highest purity standards. Super Refining is a proprietary
etken madde (API) ile ters etkileÅŸimi Ã¶nleyen, polar safsÄ±z-   refining process which removes polar impurities, prevent-
lÄ±klarÄ± uzaklaÅŸtÄ±ran Ã¶zel bir rafinasyon iÅŸlemidir. Croda Su-  ing adverse interactions with Active Pharmaceutical Ingre-
per Refining iÅŸlemi, hÃ¼cresel tahriÅŸ potansiyelini en aza in-  dients (APIs). Crodaâ€™s Super Refining process also enhances
direrek, farmasÃ¶tik formÃ¼lasyonlarÄ±n stabilitesini arttÄ±rÄ±r.   the stability of pharmaceutical formulations, minimising the
Penetrasyonu ArttÄ±rmak                                         potential of cellular irritation.
Super Refined Arlasolve DMI epidermise penetrasyon ar-         Enhancing Penetration
tÄ±rÄ±cÄ± olarak rol oynamaktadÄ±r. Dimetil Ä°zosorbit, Stratum     Super Refined Arlasolve DMI acts as a penetration enhancer
Corneumâ€™e nÃ¼fuz eder ve
bu sayede, cilt tabakasÄ±nÄ±n                                                                            through the epidermis. Di-
polaritesini arttÄ±rÄ±r. Cilt po-                                                                        methyl isosorbide penetrates
laritesindeki bu deÄŸiÅŸiklik,                                                                           the stratum corneum and in
epidermise bu bileÅŸenle-                                                                               doing so, increases the po-
rin iyi bir ÅŸekilde taÅŸÄ±nma-                                                                           larity of the skin layer. This
sÄ±yla sonuÃ§lanan, Stratum                                                                              change in polarity improves
Corneum iÃ§indeki hidrofi-                                                                              the partitioning co-efficient
lik aktif madde bÃ¶lme kat-                                                                             of hydrophilic actives into
sayÄ±sÄ±nÄ± artÄ±rÄ±r1. Åekil 1, for-                                                                       the stratum corneum, result-
mÃ¼lasyona %10 DMI ek-                                                                                  ing in an improved delivery
lenmesi ile problemin kay-                                                                             of those ingredients through
naÄŸÄ±na ulaÅŸmada epider-                                                                                the epidermis1. Figure 1 illus-
mise taÅŸÄ±nan etken mad-                                                                                trates that the addition of
denin miktarÄ±nda %15 ar-                                                                               10% DMI to a formulation
tÄ±ÅŸÄ± ile sonuÃ§landÄ±ÄŸÄ±nÄ± gÃ¶s-                                                                           resulted in a 15% increase
termektedir.                                                                                           in the amount of active de-
                                                                                                       livered into the epidermis,
                                                                                                       addressing the source of the
                                                                                                       problem.

                       Åekil 1: Super Refined Arlasolve DMI iÃ§eren ve iÃ§ermeyen iki O / W formÃ¼lasyonunda hidrofilik etken
                                                                   maddenin topikal taÅŸÄ±nma etkinliÄŸi.

                       Figure 1: Topical delivery efficacy of hydrophilic active in two O/W formulations, one with and one
                                                                 without Super Refined Arlasolve DMI.

72 MayÄ±s - May / Haziran - June 2016</code></pre>
     	</div>
    
     </div>
     <div id="content-bottom">
       <div id="content-bottom2">
         <table width="110" border="0" cellspacing="0" cellpadding="0">
           <tr>
             <td width="22%" height="44"><a href="page73.html"><img src="images/previous.png" width="26" height="19" id="Image2" onmouseover="MM_swapImage('Image2','','images/previous2.png',1)" onmouseout="MM_swapImgRestore()" /></a></td>
             <td width="43%">
             	&nbsp;&nbsp;&nbsp;<a href="page69.html">69</a>&nbsp;&nbsp;&nbsp;<a href="page70.html">70</a>&nbsp;&nbsp;&nbsp;<a href="page71.html">71</a>&nbsp;&nbsp;&nbsp;<a href="page72.html">72</a>&nbsp;&nbsp;&nbsp;<a href="page73.html">73</a>&nbsp;&nbsp;&nbsp;<a href="page74.html">74</a>&nbsp;&nbsp;&nbsp;<a href="page75.html">75</a>&nbsp;&nbsp;&nbsp;<a href="page76.html">76</a>&nbsp;&nbsp;&nbsp;<a href="page77.html">77</a>&nbsp;&nbsp;&nbsp;<a href="page78.html">78</a>&nbsp;&nbsp;&nbsp;<a href="page79.html">79</a>
             </td>
             <td width="35%"><a href="page75.html"><img src="images/next.png" width="26" height="19" id="Image1" onmouseover="MM_swapImage('Image1','','images/next2.png',1)" onmouseout="MM_swapImgRestore()" /></a></td>
           </tr>
         </table>
       </div>
     </div>
  </div>
</div>
<div id="right-button">
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p>&nbsp;</p>
  <p><a href="page75.html"><img src="images/next_big.png" width="90" height="80" /></a></p>
</div>


</div>
</body>
</html>